Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Sina Ghaemmaghami
PROVIDER: MSV000080752 | MassIVE | Wed Mar 29 06:20:00 BST 2017
SECONDARY ACCESSION(S): PXD003558
REPOSITORIES: MassIVE
Cell reports 20160303 10
In eukaryotic cells, macroautophagy is a catabolic pathway implicated in the degradation of long-lived proteins and damaged organelles. Although it has been demonstrated that macroautophagy can selectively degrade specific targets, its contribution to the basal turnover of cellular proteins has not been quantified on proteome-wide scales. In this study, we created autophagy-deficient primary human fibroblasts and quantified the resulting changes in basal degradative flux by dynamic proteomics. O ...[more]