Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD003790PRJNA318019
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Arie Admon
PROVIDER: MSV000080843 | MassIVE | Fri Mar 31 21:09:00 BST 2017
SECONDARY ACCESSION(S): PXD003790
REPOSITORIES: MassIVE
Shraibman Bracha B Kadosh Dganit Melamed DM Barnea Eilon E Admon Arie A
Molecular & cellular proteomics : MCP 20160713 9
Treatment of cancer cells with anticancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor's gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA peptides on the surface of the tumor cells and be developed into anticancer immunotherapeutics. For example, the DNA methyl transferase inhibitor, 5-aza-2'-deoxycytidine (Decitabine) has limited antitumor ...[more]