Dataset Information

Human temporal neocortex brain LC-MS

ABSTRACT: We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arrays.

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kim Kultima

PROVIDER: MSV000081016 | MassIVE | Wed Apr 26 19:57:00 BST 2017

SECONDARY ACCESSION(S): PXD004499

REPOSITORIES: MassIVE

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Publications

Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.

Musunuri Sravani S Khoonsari Payam Emami PE Mikus Maria M Wetterhall Magnus M Häggmark-Mänberg Anna A Lannfelt Lars L Erlandsson Anna A Bergquist Jonas J Ingelsson Martin M Shevchenko Ganna G Nilsson Peter P Kultima Kim K

Journal of Alzheimer's disease : JAD 20161001 4

<h4>Background</h4>Alzheimer's disease (AD) is a chronic neurodegenerative disorder accounting for more than 50% of all dementia cases. AD neuropathology is characterized by the formation of extracellular plaques and intracellular neurofibrillary tangles consisting of aggregated amyloid-β and tau, respectively. The disease mechanism has only been partially elucidated and is believed to also involve many other proteins.<h4>Objective</h4>This study intended to perform a proteomic profiling of post ...[more]

PMID: 27636840

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