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Proteomic Analysis of Hypoxic Human Lung Epithelial Cells

ABSTRACT: H441 cell proteome was sequenced via SILAC and LC-MS/MS method to identify hypoxia-responsive proteins

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Vrushank Dave

PROVIDER: MSV000081087 | MassIVE | Mon May 15 17:53:00 BST 2017

SECONDARY ACCESSION(S): PXD005187

REPOSITORIES: MassIVE

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Publications

Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis.

Kathiriya Jaymin J JJ Nakra Niyati N Nixon Jenna J Patel Puja S PS Vaghasiya Vijay V Alhassani Ahmed A Tian Zhi Z Allen-Gipson Diane D Davé Vrushank V

Cell death discovery 20170410

Idiopathic pulmonary fibrosis (IPF) is characterized by lung remodeling arising from epithelial injury, aberrant fibroblast growth, and excessive deposition of extracellular matrix. Repeated epithelial injury elicits abnormal wound repair and lung remodeling, often associated with alveolar collapse and edema, leading to focal hypoxia. Here, we demonstrate that hypoxia is a physiological insult that contributes to pulmonary fibrosis (PF) and define its molecular roles in profibrotic activation of ...[more]

PMID: 28417017

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