Proteomics

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ITRAQ8 analysis of control and neuronal ceroid lipofuscinosis human brain samples.

ABSTRACT: iTRAQ8 analysis of autopsy samples representing brain and cerebrospinal fluid from neuronal ceroid lipofuscinosis patients and controls.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: David Sleat   Peter Lobel  

PROVIDER: MSV000081143 | MassIVE | Tue Jun 06 13:01:00 BST 2017

SECONDARY ACCESSION(S): PXD006667

REPOSITORIES: MassIVE

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Publications

Proteomic Analysis of Brain and Cerebrospinal Fluid from the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Potential Biomarkers.

Sleat David E DE   Tannous Abla A   Sohar Istvan I   Wiseman Jennifer A JA   Zheng Haiyan H   Qian Meiqian M   Zhao Caifeng C   Xin Winnie W   Barone Rosemary R   Sims Katherine B KB   Moore Dirk F DF   Lobel Peter P  

Journal of proteome research 20170828 10

Clinical trials have been conducted for the neuronal ceroid lipofuscinoses (NCLs), a group of neurodegenerative lysosomal diseases that primarily affect children. Whereas clinical rating systems will evaluate long-term efficacy, biomarkers to measure short-term response to treatment would be extremely valuable. To identify candidate biomarkers, we analyzed autopsy brain and matching CSF samples from controls and three genetically distinct NCLs due to deficiencies in palmitoyl protein thioesteras  ...[more]

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