Proteomics

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HATRIC-based identification of receptors for orphan ligands


ABSTRACT: Cellular responses depend on the interactions of extracellular ligands, such as nutrients, growth factors, or drugs, with specific cell-surface receptors. The sensitivity of these interactions to non-physiological conditions, however, makes them challenging to study using in vitro assays. Here we present HATRIC, a technology that successfully identifies target receptors for ligands ranging from small molecules to intact viruses at physiological pH from as few as 1 million cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Bernd Wollscheid  

PROVIDER: MSV000081228 | MassIVE | Fri Jul 07 13:44:00 BST 2017

REPOSITORIES: MassIVE

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