Proteomics

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Youn_et_al_RNAbodies_SAINT3073

ABSTRACT: Youn et al. High-density proximity mapping reveals the subcellular organization of mRNA-associated granules and bodies (SAINTexpress 3073) Sample information related to MASSIVE submission Youn_et_al_RNAbodies_SAINT 3073 (data -indendent acquisition, MSPLIT analysis).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000081422 | MassIVE | Mon Aug 07 13:53:00 BST 2017

REPOSITORIES: MassIVE

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Publications

mRNA processing, transport, translation, and ultimately degradation involve a series of dedicated protein complexes that often assemble into large membraneless structures such as stress granules (SGs) and processing bodies (PBs). Here, systematic in vivo proximity-dependent biotinylation (BioID) analysis of 119 human proteins associated with different aspects of mRNA biology uncovers 7424 unique proximity interactions with 1,792 proteins. Classical bait-prey analysis reveals connections of hundr  ...[more]

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