Proteomics

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EMI_TB_PROTEOMICS_CSIC

ABSTRACT: Three complete TMTs for saliva and three complete TMTs for sputum samples from active tuberculosis patients (TB) and their household infected (LTI) and uninfected (nonLTI) contacts. Parallel Reaction Monitoring (PRM) analysis in sputum samples of infected and uninfected contacts to measure levels of MUC7, CYST, CAH6 and PERL.

INSTRUMENT(S): LTQ Orbitrap, Orbitrap Fusion

ORGANISM(S): Human

SUBMITTER: Monica Carrera  

PROVIDER: MSV000081574 | MassIVE | Mon Oct 02 01:42:00 BST 2017

REPOSITORIES: MassIVE

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High-resolution quantitative proteomics applied to the study of the specific protein signature in the sputum and saliva of active tuberculosis patients and their infected and uninfected contacts.

Mateos Jesús J   Estévez Olivia O   González-Fernández África Á   Anibarro Luis L   Pallarés Ángeles Á   Reljic Rajko R   Gallardo José M JM   Medina Isabel I   Carrera Mónica M  

Journal of proteomics 20190118

Our goal was to establish panels of protein biomarkers that are characteristic of patients with microbiologically confirmed pulmonary tuberculosis (TB) and their contacts, including latent TB-infected (LTBI) and uninfected patients. Since the first pathogen-host contact occurs in the oral and nasal passages the saliva and sputum were chosen as the biological fluids to be studied. Quantitative shotgun proteomics was performed using a LTQ-Orbitrap-Elite platform. For active TB patients, both fluid  ...[more]

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