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Quantitative Proteomics Study (iTRAQ) of Progeria Cell Lines

ABSTRACT: A quantitative proteomic study of three HGPS cell lines from affected patients and three healthy controls from unaffected progenitors

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jesus Mateos

PROVIDER: MSV000081576 | MassIVE | Tue Oct 03 01:21:00 BST 2017

REPOSITORIES: MassIVE

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Publications

Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging.

Mateos Jesús J Fafián-Labora Juan J Morente-López Miriam M Lesende-Rodriguez Iván I Monserrat Lorenzo L Ódena María A MA Oliveira Eliandre de E de Toro Javier J Arufe María C MC

PloS one 20181031 10

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the molecular mechanisms underlying HGPS are still not fully understood and, currently, there is no cure for the patients, which die at a mean age of thirteen. With the aim of unraveling non-previously altered molecular pathways in the premature aging process, human cell lines from HGPS patie ...[more]

PMID: 30379953

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