Proteomics

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MuSt multiomics

ABSTRACT: Multiomics of faecal samples collected from individuals in families with multiple cases of type 1 diabetes mellitus (T1DM) over 3 or 4 months. Metagenomic and metatranscriptomic sequencing and metaproteomics were carried out, as well as whole human genome sequencing. Phenotypic data is available.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mixed Culture Metagenome (ncbitaxon:1306859)

SUBMITTER: Paul Wilmes  

PROVIDER: MSV000081630 | MassIVE | Thu Oct 19 06:38:00 BST 2017

SECONDARY ACCESSION(S): PXD003791

REPOSITORIES: MassIVE

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Publications

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes.

Heintz-Buschart Anna A   May Patrick P   Laczny Cédric C CC   Lebrun Laura A LA   Bellora Camille C   Krishna Abhimanyu A   Wampach Linda L   Schneider Jochen G JG   Hogan Angela A   de Beaufort Carine C   Wilmes Paul P  

Nature microbiology 20161010

The gastrointestinal microbiome is a complex ecosystem with functions that shape human health. Studying the relationship between taxonomic alterations and functional repercussions linked to disease remains challenging. Here, we present an integrative approach to resolve the taxonomic and functional attributes of gastrointestinal microbiota at the metagenomic, metatranscriptomic and metaproteomic levels. We apply our methods to samples from four families with multiple cases of type 1 diabetes mel  ...[more]

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