Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD002801PRJNA295057
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Steven Gygi
PROVIDER: MSV000081696 | MassIVE | Wed Nov 08 18:15:00 GMT 2017
SECONDARY ACCESSION(S): PXD002801
REPOSITORIES: MassIVE
Nature 20160615 7608
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide transcript and protein expression in livers from 192 Diversity outbred mice, we ide ...[more]