Proteomics

Dataset Information

2

Protein Turnover Rates in Normal and Hypertrophy Mouse Hearts

ABSTRACT: This dataset contains the in vivo turnover rate information of ~3,000 proteins from the mouse heart. Data from six common laboratory mouse strains with differential responses to isoproterenol are included

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Peipei Ping  

PROVIDER: MSV000081697 | MassIVE | Wed Nov 08 18:56:00 GMT 2017

SECONDARY ACCESSION(S): PXD002870

REPOSITORIES: MassIVE

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Publications

Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of protein turnover is widely implicated in diverse pathologies from heart failure to neurodegenerations. Information on global protein dynamics therefore has the potential to expand the depth and scope of disease phenotyping and therapeutic strategies. Using an integrated platform of metabolic labeling, high-resolution mass spectrometry and comp  ...[more]