Dataset Information

The Functions of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo

ABSTRACT: This dataset includes BioID for SEC23A and SEC23B. The paper describes the functional redundancy of these two gene paralogs in the context of human disease.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras

PROVIDER: MSV000081703 | MassIVE | Thu Nov 09 13:26:00 GMT 2017

SECONDARY ACCESSION(S): PXD008180

REPOSITORIES: MassIVE

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Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.

Khoriaty Rami R Hesketh Geoffrey G GG Bernard Amélie A Weyand Angela C AC Mellacheruvu Dattatreya D Zhu Guojing G Hoenerhoff Mark J MJ McGee Beth B Everett Lesley L Adams Elizabeth J EJ Zhang Bin B Saunders Thomas L TL Nesvizhskii Alexey I AI Klionsky Daniel J DJ Shavit Jordan A JA Gingras Anne-Claude AC Ginsburg David D

Proceedings of the National Academy of Sciences of the United States of America 20180731 33

Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (<i>Sec23a</i> and <i>Sec23b</i>). In humans, SEC23B deficiency results in congenital dyserythropoietic anemia type-II (CDAII), while SEC23A deficiency results in a skeletal phenotype (with normal red blood cells). These distinct clinical disorders, together ...[more]

PMID: 30065114

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