Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus

ABSTRACT: Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Leah Shriver Lars Pache Adolfo Garcia-Sastre

PROVIDER: MSV000081785 | MassIVE | Wed Dec 06 19:20:00 GMT 2017

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS - FluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus

Project description:Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.

2017-12-06 | MSV000081785 | GNPS

Mouse lung transcriptome response to infection with H1N1, H3N2, and H5N1 influenza virus.

Project description:The cellular transcriptome of C57BL/6 mouse lungs was profiled by mRNA-Seq analysis at multiple time points in response to infection with influenza A/California/04/09 (H1N1), A/Wyoming/03/03 (H3N2), and A/Vietnam/1203/04 (H5N1) HALo virus. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53. A/Wyoming/03/03 (H3N2) influenza virus replicates poorly in mice and lung tissue collected from mice inoculated with this virus did not carry viral loads detectable by plaque assay.

2017-05-05 | GSE98527 | GEO

ICL010 - Infection of Calu-3 cells with H1N1 influenza virus A/Netherlands/602/2009

Project description:Differential expression was determined in Calu-3 cells between mock infected and infected with H1N1 influenza virus A/Netherlands/602/2009 at nine time points post-infection. As a comparison, cells were also infected with A/CA/04/2009 H1N1 influenza virus at 4 time points post-infection. Cells were infected at an MOI of 3.0. For the A/Netherlands/602/09-infected and mock-infected cells, samples were collected at 0, 3, 7, 12, 18, 24, 30, 36, and 48 hours post-infection (h.p.i.). For the A/California/04/2009-infected cells, samples were collected at 0, 12, 24, and 48 h.p.i. Samples were collected in triplicate.

2012-09-13 | E-GEOD-40844 | biostudies-arrayexpress

An ultrasensitive mechanism regulates influenza virus-induced inflammation

Project description:Whole-genome, time-course data was developed from the lungs of influenza infected mice to better characterize the dynamics of the host immune response during infection. Lung for microarray studies were obtained from female, five-week old C57BL/6Js infected with influenza viruses. Forty-two animals per group were inoculated with 10^5 PFU of A/Kawasaki/UTK-4/09 H1N1 virus [Kawasaki], A/California/04/09 (H1N1) virus (pH1N1) [SOIV], A/Vietnam/1203/04 H5N1 virus (H5N1), 10^3 PFU A/Vietnam/1203/04 H5N1 virus (H5N1) [VN1203] or mock-infected with PBS. Spanning the first week of the infections, three animals per infection group were sacrificed at 14 predetermined time points, lungs isolated and the homogenate was used to assess changes in genes expression over time and between infections.

2015-06-12 | E-GEOD-63786 | biostudies-arrayexpress

Human monocyte-derived macrophage (MDM) cell transcriptome response to infection with H1N1, H3N2, and H5N1 influenza virus.

Project description:Human monocyte-derived macrophages (MDM) serve as a model for resident alveolar macrophages (AM) in the human respiratory tract. mRNA-Seq analysis was used to profile the cellular transcriptome of MDM cells at multiple time points in response to infection with influenza A/California/04/09 (H1N1), A/Wyoming/03/03 (H3N2), and A/Vietnam/1203/04 (H5N1) HALo virus. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.

2017-05-05 | GSE97672 | GEO

Human tracheobronchial epithelial (HTBE) cell transcriptome response to infection with H1N1, H3N2, and H5N1 influenza virus.

Project description:Human tracheobronchial epithelial (HTBE) cells are considered to serve as a good correlate of influenza virus infection in the human respiratory tract. mRNA-Seq analysis was used to profile the cellular transcriptome of HTBE cells at multiple time points in response to infection with influenza A/California/04/09 (H1N1), A/Wyoming/03/03 (H3N2), and A/Vietnam/1203/04 (H5N1) HALo virus. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.

2016-10-27 | GSE89008 | GEO

H3K27ac profiling of human tracheobronchial epithelial cells during infection with H1N1, H3N2, and H5N1 influenza virus [ChIP-seq]

Project description:Human tracheobronchial epithelial (HTBE) cells are considered to serve as a good correlate of influenza virus infection in the human respiratory tract. ChIP-Seq analysis was used to profile histone acetylation (H3K27ac) in HTBE cells at multiple time points in response to infection with influenza A/California/04/09 (H1N1), A/Wyoming/03/03 (H3N2), and A/Vietnam/1203/04 (H5N1) HALo virus. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.

2018-12-14 | GSE113702 | GEO

GATM PPMO knockdown affects host response to H1N1 influenza infection in mouse lungs

Project description:The GATM gene shows strong transcriptional regulation during influenza infection and increased GATM transcription correlates with peak viral titers in the lung. In order to investigate an in vivo role for GATM during influenza infection, we created a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) to disrupt GATM translation. In our study, mice received a GATM-specific PPMO or scrambled PPMO once per day for two days, and then were subsequently infected with an H1N1 (A/California/04/2009) strain of IAV or PBS as a mock infection control. Mouse lungs were harvested three days post-infection and analyzed via RNA sequencing.

2021-08-02 | GSE181246 | GEO

FluOMICS - Metabolomics analysis of HTBE cells infected with H1N1 influenza virus

Project description:Metabolomics analysis of human tracheobronchial epithelial (HTBE) cells was conducted at multiple time points in response to infection with influenza A/California/04/09 (H1N1) virus or mock infection.

2017-12-06 | MSV000081782 | MassIVE

ICL010 - Infection of Calu-3 cells with H1N1 influenza virus A/Netherlands/602/2009

2012-09-13 | GSE40844 | GEO