Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
H. Alexander Ebhardt
PROVIDER: MSV000081956 | MassIVE | Mon Jan 22 06:22:00 GMT 2018
REPOSITORIES: MassIVE
Publications
Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer.
Ebhardt H Alexander HA Root Alex A Liu Yansheng Y Gauthier Nicholas Paul NP Sander Chris C Aebersold Ruedi R
NPJ systems biology and applications 20180702
In the United States alone one in five newly diagnosed cancers in men are prostate carcinomas (PCa). Androgen receptor (AR) status and the PI3K-AKT-mTOR signal transduction pathway are critical in PCa. After initial response to single drugs targeting these pathways resistance often emerges, indicating the need for combination therapy. Here, we address the question of efficacy of drug combinations and development of resistance mechanisms to targeted therapy by a systems pharmacology approach. We ...[more]
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