Proteomics

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Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes despite temporal variations in microbial taxa, genomes, and proteomes


ABSTRACT: Longitudinal metaproteomics data set looking at the gut microbiome metaproteomes of fivepost-surgery Crohn's Disease patients for five time points over the course of a year.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Human Microbiome

SUBMITTER: Robert L. Hettich  

PROVIDER: MSV000082823 | MassIVE | Thu Aug 16 08:10:00 BST 2018

REPOSITORIES: MassIVE

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Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes of Crohn's remission patients despite temporal variations in microbial taxa, genomes, and proteomes.

Blakeley-Ruiz J Alfredo JA   Erickson Alison R AR   Cantarel Brandi L BL   Xiong Weili W   Adams Rachel R   Jansson Janet K JK   Fraser Claire M CM   Hettich Robert L RL  

Microbiome 20190211 1


<h4>Background</h4>The gut microbiome plays a fundamental role in the human host's overall health by contributing key biological functions such as expanded metabolism and pathogen defense/immune control. In a healthy individual, the gut microbiome co-exists within the human host in a symbiotic, non-inflammatory relationship that enables mutual benefits, such as microbial degradation of indigestible food products into small molecules that the host can utilize, and enhanced pathogen defense. In ab  ...[more]

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