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The N-cadherin interactome in primary cardiomyocytes

ABSTRACT: Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel trypsin digested and the resulting tryptic peptides were analyzed on an LTQ Orbitrap Velos.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus

SUBMITTER: Adam V. Kwiatkowski  

PROVIDER: MSV000083356 | MassIVE | Wed Jan 23 17:36:00 GMT 2019

REPOSITORIES: MassIVE

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The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics.

Li Yang Y   Merkel Chelsea D CD   Zeng Xuemei X   Heier Jonathon A JA   Cantrell Pamela S PS   Sun Mai M   Stolz Donna B DB   Watkins Simon C SC   Yates Nathan A NA   Kwiatkowski Adam V AV  

Journal of cell science 20190211 3

The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart function. Yet little is known about the molecular composition of the cardiomyocyte AJ or how it is organized to function under mechanical load. Here, we define the architecture, dynamics and proteome of the cardiomyocyte AJ. Mouse neo  ...[more]

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