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PProteomic analysis of enhanced cellular effects of electroporation and cisplatin in triple-negative breast cancer cells

ABSTRACT: We performed a comprehensive and label-free quantitative proteomic analysis of the human adenocarcinoma epithelial TNBC cells (MDA-MB-231) treated with Cisplatin (CsP) and Cisplatin with EP (EP+CsP). We identified hundreds of differentially expressed proteins that defines molecular mechanisms involved in cellular responses of MDA-MB-231 cells to ECT. The underlying dataset represents a valuable resource for mechanistic studies and for the validation of knowledge gained from this study in the future using animal models. The systemic data should build a foundation for a better understanding of the mechanisms of the cytotoxicity of the Cisplatin as a potent anticancer drug.

INSTRUMENT(S): Q Exactive Orbitrap HF mass spectrometer

ORGANISM(S): Mda-mb-231 Tnbc Model Cells

SUBMITTER: Rajeswari Sundararajan

PROVIDER: MSV000083360 | MassIVE | Thu Jan 24 14:07:00 GMT 2019

REPOSITORIES: MassIVE

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