Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE126344
INSTRUMENT(S): TripleTOF 5600, LTQ
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911)
SUBMITTER: Jean-Philippe Lambert
PROVIDER: MSV000083486 | MassIVE | Tue Feb 26 09:05:00 GMT 2019
SECONDARY ACCESSION(S): PXD012883
REPOSITORIES: MassIVE
Current biology : CB 20190704 14
Mediator is a large protein complex required for basal and regulated expression of most RNA polymerase II (RNAP II)-transcribed genes, in part due to its interaction with and phosphorylation of the conserved C-terminal domain (CTD) of Rpb1 [1, 2]. Mediator has been implicated in many aspects of gene expression including chromatin looping [3], higher-order chromatin folding [4], mRNA processing [5] and export [6], and transcriptional memory [7]. Mediator is thought to have played a major role dur ...[more]