TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
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ABSTRACT: The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro-inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here we show that TAK1, a kinase involved in immune signaling, negatively regulates p62 action in autophagy.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Mike Mandell
PROVIDER: MSV000083679 | MassIVE | Fri Apr 12 00:09:00 BST 2019
REPOSITORIES: MassIVE
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