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Hesketh_BioID_HOPS-mTORC1_2019

ABSTRACT: This submission is associated with a paper by Hesketh et al. that identifies the GATOR-Rag GTPase pathway as a negative regulator of mTORC1 activation by lysosome-derived amino acids.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras

PROVIDER: MSV000084159 | MassIVE | Tue Jul 30 13:34:00 BST 2019

REPOSITORIES: MassIVE

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The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.

Hesketh Geoffrey G GG Papazotos Fotini F Pawling Judy J Rajendran Dushyandi D Knight James D R JDR Martinez Sebastien S Taipale Mikko M Schramek Daniel D Dennis James W JW Gingras Anne-Claude AC

Science (New York, N.Y.) 20201001 6514

The mechanistic target of rapamycin complex 1 (mTORC1) couples nutrient sufficiency to cell growth. mTORC1 is activated by exogenously acquired amino acids sensed through the GATOR-Rag guanosine triphosphatase (GTPase) pathway, or by amino acids derived through lysosomal degradation of protein by a poorly defined mechanism. Here, we revealed that amino acids derived from the degradation of protein (acquired through oncogenic Ras-driven macropinocytosis) activate mTORC1 by a Rag GTPase-independen ...[more]

PMID: 33060361

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