Proteomics

Dataset Information

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In-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics


ABSTRACT: In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Ute Distler  

PROVIDER: MSV000084240 | MassIVE | Tue Aug 27 15:05:00 BST 2019

SECONDARY ACCESSION(S): PXD000590

REPOSITORIES: MassIVE

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In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.

Distler Ute U   Schmeisser Michael J MJ   Pelosi Assunta A   Reim Dominik D   Kuharev Jörg J   Weiczner Roland R   Baumgart Jan J   Boeckers Tobias M TM   Nitsch Robert R   Vogt Johannes J   Tenzer Stefan S  

Proteomics 20141018 21-22


Located at neuronal terminals, the postsynaptic density (PSD) is a highly complex network of cytoskeletal scaffolding and signaling proteins responsible for the transduction and modulation of glutamatergic signaling between neurons. Using ion-mobility enhanced data-independent label-free LC-MS/MS, we established a reference proteome of crude synaptosomes, synaptic junctions, and PSD derived from mouse hippocampus including TOP3-based absolute quantification values for identified proteins. The fi  ...[more]

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