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Environmental Pollutant Induced Cellular Injury is Reflected in Exosomes from Placental Explants

ABSTRACT: Environmental exposure of placental explants did not change the quantity of exosomes or their characteristics. However, exosome cargo composition was changed by specific pollutant to reflect a biochemical signature suggestive of placental nuclear and cellular injury and inflammation.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ramkumar Menon

PROVIDER: MSV000084274 | MassIVE |

SECONDARY ACCESSION(S): PXD015321

REPOSITORIES: MassIVE

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Environmental pollutant induced cellular injury is reflected in exosomes from placental explants.

Sheller-Miller Samantha S Radnaa Enkhtuya E Arita Yuko Y Getahun Darios D Jones Richard J RJ Peltier Morgan R MR Menon Ramkumar R

Placenta 20191017

<h4>Introduction</h4>Exosomes are intercellular signaling vesicles whose cargo reflects the physiological status of the cell of their origin and can regulate gene expression in other tissues. Polybrominated diphenyl ethers (PBDEs) and bisphenols (A [BPA], Tetrabromobisphenol A [TBBPA], and 2,4,6-Tribromophenol [TBP]) are common environmental pollutants known to increase the risk for spontaneous preterm birth (PTB). We hypothesized that placental exposure to these environmental pollutants causes ...[more]

PMID: 31675489

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