Dataset Information

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis or NAFLD with normal glucose tolerance or diabetes, revealed 8 significantly changing (ALDOB, APOM, LGALS3BP, PIGR, VTN, IGHD, FCGBP and AFM), two of which are already linked to liver disease. Polymeric immunoglobulin receptor (PIGR) was significantly elevated in both cohorts with a 2.7-fold expression change in NAFLD and 4-fold change in cirrhosis and was further validated in mouse models. Furthermore, a global correlation map of clinical and proteomic data strongly associated DPP4, ANPEP, TGFBI, PIGR, and APOE to NAFLD and cirrhosis. DPP4 is a known drug target in diabetes. ANPEP and TGFBI are of interest because of their potential role in extracellular matrix remodeling in fibrosis.

OTHER RELATED OMICS DATASETS IN: PXD012056PXD011839

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Matthias Mann

PROVIDER: MSV000084333 | MassIVE |

SECONDARY ACCESSION(S): PXD011839

REPOSITORIES: MassIVE

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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Niu Lili L Geyer Philipp E PE Wewer Albrechtsen Nicolai J NJ Gluud Lise L LL Santos Alberto A Doll Sophia S Treit Peter V PV Holst Jens J JJ Knop Filip K FK Vilsbøll Tina T Junker Anders A Sachs Stephan S Stemmer Kerstin K Müller Timo D TD Tschöp Matthias H MH Hofmann Susanna M SM Mann Matthias M

Molecular systems biology 20190301 3

Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma proteome profiling of 48 patients with and without cirrhosis or NAFLD revealed six statistically significantly changing proteins (ALDOB, APOM, LGALS3BP, PIGR, VTN, and AFM), two of which are already linked to liver disease. Polymeric immunoglobulin recepto ...[more]

PMID: 30824564

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