Proteomics

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Phosphoproteomic profiling of Acute Myeloid Leukaemia


ABSTRACT: Acute Myeloid Leukaemia (AML) carries a 5 year survival rate of just 24%. Toxic chemotherapy regimens remain the backbone of standard of care for AML. The FLT3 tyrosine kinase is a recognised AML oncogene, with FLT3 activating mutations occurring in approximately one third of all AML patients. However, therapeutic targeting of FLT3 has proven difficult as monotherapy, with the development of drug resistance and relapse. Characterisation of the signalling pathways regulated by mutant FLT3 is required to identify better therapeutic strategies.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Matt Dun   Nikki Verrills  

PROVIDER: MSV000084730 | MassIVE | Fri Dec 20 01:35:00 GMT 2019

SECONDARY ACCESSION(S): PXD016860

REPOSITORIES: MassIVE

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