Dataset Information

Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism

ABSTRACT: submission for the paper "Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism"

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jason Held

PROVIDER: MSV000084785 | MassIVE | Thu Jan 09 19:18:00 GMT 2020

SECONDARY ACCESSION(S): PXD017043

REPOSITORIES: MassIVE

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Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming.

Brashears Caitlyn B CB Barlin Meltem M Ehrhardt William R WR Rathore Richa R Schultze Matthew M Tzeng Shin-Chen SC Van Tine Brian A BA Held Jason M JM

Cell death & disease 20200820 8

Arginine auxotrophy due to the silencing of argininosuccinate synthetase 1 (ASS1) occurs in many carcinomas and in the majority of sarcomas. Arginine deiminase (ADI-PEG20) therapy exploits this metabolic vulnerability by depleting extracellular arginine, causing arginine starvation. ASS1-negative cells develop resistance to ADI-PEG20 through a metabolic adaptation that includes re-expressing ASS1. As arginine-based multiagent therapies are being developed, further characterization of the changes ...[more]

PMID: 32814773

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