Proteomics

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Proteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia

ABSTRACT: Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Janne Lehti??  

PROVIDER: MSV000084862 | MassIVE | Wed Jan 29 22:39:00 GMT 2020

SECONDARY ACCESSION(S): PXD010175

REPOSITORIES: MassIVE

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Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples from hyperdiploid and ETV6/RUNX1-positive pediatric ALL. We show that CTCF and cohesin, which are mas  ...[more]

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