Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Prof. Dr. Matthias Mann
PROVIDER: MSV000084941 | MassIVE | Sat Feb 08 11:13:00 GMT 2020
SECONDARY ACCESSION(S): PXD001250
REPOSITORIES: MassIVE
Sharma Kirti K Schmitt Sebastian S Bergner Caroline G CG Tyanova Stefka S Kannaiyan Nirmal N Manrique-Hoyos Natalia N Kongi Karina K Cantuti Ludovico L Hanisch Uwe-Karsten UK Philips Mari-Anne MA Rossner Moritz J MJ Mann Matthias M Simons Mikael M
Nature neuroscience 20151102 12
Brain transcriptome and connectome maps are being generated, but an equivalent effort on the proteome is currently lacking. We performed high-resolution mass spectrometry-based proteomics for in-depth analysis of the mouse brain and its major brain regions and cell types. Comparisons of the 12,934 identified proteins in oligodendrocytes, astrocytes, microglia and cortical neurons with deep sequencing data of the transcriptome indicated deep coverage of the proteome. Cell type-specific proteins d ...[more]