Proteomics of plasma exosomes in human cystic echinococcosis
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ABSTRACT: Exosomes represent an important way of cell-cell communication. Their release into the bloodstream is similar to sending bottle messages that can safely reach (distant) target tissues and cells. In disease contexts, these vesicles provide a suitable source of markers of pathogenesis or carcinogenesis, as well as of the immune response and the host-pathogens interplay. In cystic echinococcosis (CE), the availability of a marker-based blood test would represent an extraordinary advantage for disease diagnosis, staging and follow-up. The active search for CE carriers, realized by ultrasound surveys of around 25,000 individuals in the HERACLES project, finally allowed the implementation of a proteomic biomarker discovery analysis based on plasma exosomes from CE patients. The identification of parasite proteins likely within host exosomes supports this important exchange of information and suggests possible molecular markers to be validated. Further, our study yielded valuable insights into the types of response mounted by the immune system in the presence of either active or inactive CE, supporting previous evidence with data obtained in vivo from a large, well-characterized cohort of subjects
INSTRUMENT(S): LTQ XL ETD
ORGANISM(S): Homo Sapiens And Echinococcus Granoulosus
SUBMITTER: FEDERICA FRATINI
PROVIDER: MSV000085234 | MassIVE | Mon Apr 06 10:08:00 BST 2020
REPOSITORIES: MassIVE
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