Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MSP-MS for An opaque cell-specific expression program of secreted proteases and transporters allows cell-type cooperation in Candida albicans

ABSTRACT: Diverse synthetic peptide library for studying secreted protease activity for white and opaque cells of Candida albicans.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Candida Albicans (ncbitaxon:5476)

SUBMITTER: Matthew Lohse

PROVIDER: MSV000085279 | MassIVE | Mon Apr 13 17:40:00 BST 2020

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Proteomics for An opaque cell-specific expression program of secreted proteases and transporters allows cell-type cooperation in Candida albicans

Project description:Proteomic analysis of secreted proteins from Candida albicans white and opaque cells.

2020-04-13 | MSV000085283 | MassIVE

An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in <i>Candida albicans</i>.

Project description:An unusual feature of the opportunistic pathogen Candida albicans is its ability to switch stochastically between two distinct, heritable cell types called white and opaque. Here, we show that only opaque cells, in response to environmental signals, massively upregulate a specific group of secreted proteases and peptide transporters, allowing exceptionally efficient use of proteins as sources of nitrogen. We identify the specific proteases [members of the secreted aspartyl protease (SAP) family] needed for opaque cells to proliferate under these conditions, and we identify four transcriptional regulators of this specialized proteolysis and uptake program. We also show that, in mixed cultures, opaque cells enable white cells to also proliferate efficiently when proteins are the sole nitrogen source. Based on these observations, we suggest that one role of white-opaque switching is to create mixed populations where the different phenotypes derived from a single genome are shared between two distinct cell types.

| S-EPMC7536846 | biostudies-literature

Candida albicans

Project description:Candida albicans

| PRJNA308106 | ENA

Candida albicans whole cell proteomics

Project description:Proteomics analysis of Candida albicans 90028 whole cells.

2019-05-24 | PXD013457 | Pride

Candida albicans

Project description:Candida albicans Sequencing

| PRJNA327830 | ENA

Comparative genomic hybridization of Candida albicans and Candida dublinienis

Project description:Comparative genomic hybridisation between Candida albicans and Candida dublinienis using Eurogentec Candida albicans whole genome microarrays

2004-04-30 | E-MEXP-99 | biostudies-arrayexpress

Candida albicans

Project description:Candida albicans P76055 lineage

| PRJNA780091 | ENA

Candida albicans

Project description:Candida albicans D-tagatose

| PRJNA686496 | ENA

Candida albicans

Project description:Candida albicans Genome sequencing

| PRJNA271803 | ENA

Candida albicans

Project description:Candida albicans Genome sequencing