Proteomics

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EDF1 coordinates cellular responses to ribosome collisions

ABSTRACT: Raw mass spectrometry data associated with the following paper: EDF1 coordinates cellular responses to ribosome collisions. Related to Figure 2, Figure 2-figure supplement 1 and Figure 2-source data 1. Files detail: Monosome (6 BPRP fractions - labeled AO3104-3109); Polysome (6 BPRP fractions - labeled AO3098-3103)

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: J. Wade Harper   Rachel Green   Eric J. Bennett  

PROVIDER: MSV000085419 | MassIVE | Fri May 15 18:38:00 BST 2020

SECONDARY ACCESSION(S): PXD019224

REPOSITORIES: MassIVE

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Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically identify proteins associated with collided ribosomes. This approach identified Endothelial differentiation-related factor 1 (EDF1) as a novel protein recruited to collided ribosomes during translational distress. Cryo-electron microscopic analyses of  ...[more]

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