Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human brain FFPE proteomics: Epilepsy vs Control

ABSTRACT: Label-free proteomics of human brain FFPE archival tissue. Comparison of proteome composition between epilepsy and controls across 3 brain regions.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Beatrix Ueberheide

PROVIDER: MSV000085517 | MassIVE | Sun May 31 16:13:00 BST 2020

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

LFQ Human Brain FFPE Proteomics: SUDEP vs. Epilepsy

Project description:LFQ proteomics study of human brain FFPE samples between non-SUDEP and SUDEP epilepsy cases.

2020-06-01 | MSV000085523 | MassIVE

Temporal Cortex Control (mesial temporal lobe epilepsy control)

Project description:Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no mesial temporal lobe epilepsy). Keywords: disease associated splicing changes Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal lobe epilepsy

2007-01-23 | E-GEOD-6771 | biostudies-arrayexpress

Kainic acid-administered Rat brain: control vs Ketogenic diet-fed

Project description:The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model were analyzed. Two-condition experiment, Normal diet-fed rat brain vs. Ketogenic diet-fed rat brain. Duplicate per array

2010-05-19 | E-GEOD-19277 | biostudies-arrayexpress

Total Brain Control vs Brain Macrophage

Project description:Direct comparison of FACS sorted EGFP positive brain macrophages vs pooled Total Brain extract Keywords: Direct pairwise comparison

2007-07-04 | GSE6265 | GEO

Temporal Cortex Control (mesial temporal lobe epilepsy control)

2007-01-23 | GSE6771 | GEO

Blood miRNA as biomarkers of epilepsy (EARLY vs. LATE)

Project description:Epilepsy frequently develops as a result of brain insult, for example brain injury or stroke. Currently there are no tools allowing us to predict which trauma patients will eventually develop epilepsy. There is evidence that microRNAs levels are altered in the blood, making them attractive candidates for peripheral biomarkers of epilepsy. We analyzed miRNA levels in blood samples using Affymetrix microarrays 4.1 and performed comparative analysis of samples. We performed 3 comparisons: i) control animals vs. Status epilepticus animals, ii) animals which developed first spontaneous seizure around 7 days post stimulation (EARLY), or later after 21days post stimulation (LATE), iii) animals that had high or low number of seizures as determined by seizures number (EARLY vs. LATE).

2024-06-14 | GSE234940 | GEO

Blood miRNA as biomarkers of epilepsy (CTRL vs. SE)

2024-06-14 | GSE234937 | GEO

Blood miRNA as biomarkers of epilepsy (HIGH vs. LOW)

2024-06-14 | GSE234941 | GEO

Human Chromosome 11 brain tissue disease database; Alzheimer, epilepsy, and normal

Project description:Human Chromosome 11 brain tissue disease database; alzheimer, epilepsy, and normal.

2022-02-28 | PXD000803 | Pride

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

Project description:The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels of various microRNAs (miRNAs). Evidence is lacking, however, as to whether any of the circulating pool of miRNAs originates from the brain. To explore the link between circulating miRNAs and the pathophysiology of epilepsy, we first sequenced Ago2-bound miRNAs in plasma samples collected from mice subject to status epilepticus (SE) induced by intraamygdala microinjection of kainic acid. This identified time-dependent changes in plasma levels of miRNAs with known neuronal and microglial-cell origins. To explore whether the circulating miRNAs had originated from the brain, we generated mice expressing FLAG-Ago2 in neurons or microglia using tamoxifen-inducible Thy1 or Cx3cr1 promoters, respectively. FLAG immunoprecipitates from the plasma of these mice after seizures contained miRNAs, including let-7i-5p and miR-19b-3p. Taken together, these studies confirm that a portion of the circulating pool of miRNAs in experimental epilepsy originates from the brain, increasing support for miRNAs as mechanistic biomarkers of epilepsy.

2023-09-13 | GSE233890 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data