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Casz1 interactome via BioID on primary mouse retinal cells

ABSTRACT: Control versus Casz1 BioID on mouse primary retinal cells. BioID constructs were introduced via nucleofection. Cultured cells were harvested, nuclei extracted, and BioID was performed as per standard procedures.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Pierre Mattar

PROVIDER: MSV000085598 | MassIVE | Wed Jun 17 01:17:00 BST 2020

SECONDARY ACCESSION(S): PXD019828

REPOSITORIES: MassIVE

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Publications

A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.

Mattar Pierre P Jolicoeur Christine C Dang Thanh T Shah Sujay S Clark Brian S BS Cayouette Michel M

Scientific reports 20210216 1

Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechanisms underlying their function remain unclear. Here, we asked how Casz1, the mammalian orthologue of Drosophila castor, regulates competence during retinal development. We show that Casz ...[more]

PMID: 33594190

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