Proteomics

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The Global Phosphorylation Landscape of SARS-CoV-2 Infection

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limit SARS-CoV-2 infection, replication, and pathogenesis. Due to the rapid emergence of SARS-CoV-2, there currently exists a lack in the knowledge of the host cellular pathways that sustain infection and contribute to pathogenesis. Here, we present a quantitative proteomics and phosphoproteomics survey of SARS-CoV-2 infection in Vero-E6 cells.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Chlorocebus Aethiops (ncbitaxon:9534)

SUBMITTER: Dr. Nevan J. Krogan  

PROVIDER: MSV000085759 | MassIVE | Wed Jul 15 12:15:00 BST 2020

SECONDARY ACCESSION(S): PXD019113

REPOSITORIES: MassIVE

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The Global Phosphorylation Landscape of SARS-CoV-2 Infection.

Bouhaddou Mehdi M   Memon Danish D   Meyer Bjoern B   White Kris M KM   Rezelj Veronica V VV   Correa Marrero Miguel M   Polacco Benjamin J BJ   Melnyk James E JE   Ulferts Svenja S   Kaake Robyn M RM   Batra Jyoti J   Richards Alicia L AL   Stevenson Erica E   Gordon David E DE   Rojc Ajda A   Obernier Kirsten K   Fabius Jacqueline M JM   Soucheray Margaret M   Miorin Lisa L   Moreno Elena E   Koh Cassandra C   Tran Quang Dinh QD   Hardy Alexandra A   Robinot Rémy R   Vallet Thomas T   Nilsson-Payant Benjamin E BE   Hernandez-Armenta Claudia C   Dunham Alistair A   Weigang Sebastian S   Knerr Julian J   Modak Maya M   Quintero Diego D   Zhou Yuan Y   Dugourd Aurelien A   Valdeolivas Alberto A   Patil Trupti T   Li Qiongyu Q   Hüttenhain Ruth R   Cakir Merve M   Muralidharan Monita M   Kim Minkyu M   Jang Gwendolyn G   Tutuncuoglu Beril B   Hiatt Joseph J   Guo Jeffrey Z JZ   Xu Jiewei J   Bouhaddou Sophia S   Mathy Christopher J P CJP   Gaulton Anna A   Manners Emma J EJ   Félix Eloy E   Shi Ying Y   Goff Marisa M   Lim Jean K JK   McBride Timothy T   O'Neal Michael C MC   Cai Yiming Y   Chang Jason C J JCJ   Broadhurst David J DJ   Klippsten Saker S   De Wit Emmie E   Leach Andrew R AR   Kortemme Tanja T   Shoichet Brian B   Ott Melanie M   Saez-Rodriguez Julio J   tenOever Benjamin R BR   Mullins R Dyche RD   Fischer Elizabeth R ER   Kochs Georg G   Grosse Robert R   García-Sastre Adolfo A   Vignuzzi Marco M   Johnson Jeffery R JR   Shokat Kevan M KM   Swaney Danielle L DL   Beltrao Pedro P   Krogan Nevan J NJ  

Cell 20200628 3

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted ca  ...[more]

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