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Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans

ABSTRACT: Proteomic analysis of serum IgG antibody repertoire against influenza vaccine H1 (H1N1 A/California/7/2009) and H3 (H3N2 A/Texas/50/2012) in young, middle-aged, and elderly donors vaccinated with Fluzone 2013-14/14-15. Dataset consists of peak-response (days 21-28 post-vaccination) serum IgG samples eluted by affinity chromatography against H1 and H3 vaccine or hemagglutinin and the flow-throughs.

INSTRUMENT(S): LTQ Orbitrap Velos, Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: George Georgiou

PROVIDER: MSV000086108 | MassIVE |

REPOSITORIES: MassIVE

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Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans.

Jung Jiwon J Mundle Sophia T ST Ustyugova Irina V IV Horton Andrew P AP Boutz Daniel R DR Pougatcheva Svetlana S Prabakaran Ponraj P McDaniel Jonathan R JR King Gregory R GR Park Daechan D Person Maria D MD Ye Congxi C Tan Bing B Tanno Yuri Y Kim Jin Eyun JE Curtis Nicholas C NC DiNapoli Joshua J Delagrave Simon S Ross Ted M TM Ippolito Gregory C GC Kleanthous Harry H Lee Jiwon J Georgiou George G

The Journal of clinical investigation 20210701 13

Seasonal influenza vaccination elicits a diminished adaptive immune response in the elderly, and the mechanisms of immunosenescence are not fully understood. Using Ig-Seq, we found a marked increase with age in the prevalence of cross-reactive (CR) serum antibodies that recognize both the H1N1 (vaccine-H1) and H3N2 (vaccine-H3) components of an egg-produced split influenza vaccine. CR antibodies accounted for 73% ± 18% of the serum vaccine responses in a cohort of elderly donors, 65% ± 15% in la ...[more]

PMID: 34196304

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