Dataset Information

A comprehensive urine proteome database generated from patients with various renal conditions and prostate cancer

ABSTRACT: A total of 45 urine samples from 5 prostate cancer (PC) patients, 10 renal transplant patients with proven acute rejection (AR), 10 renal transplant patients with stable graft (STA), 10 non-specific proteinuria patients (NS), and 10 healthy individuals (HI), were utilized for global urine proteome profiling using 2D-LC-MS/MS. Peptides were digested with trypsin then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei-Jun Qian

PROVIDER: MSV000086484 | MassIVE | Thu Nov 19 01:59:00 GMT 2020

SECONDARY ACCESSION(S): PXD022612

REPOSITORIES: MassIVE

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Publications

A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.

Swensen Adam C AC He Jingtang J Fang Alexander C AC Ye Yinyin Y Nicora Carrie D CD Shi Tujin T Liu Alvin Y AY Sigdel Tara K TK Sarwal Minnie M MM Qian Wei-Jun WJ

Frontiers in medicine 20210413

Urine proteins can serve as viable biomarkers for diagnosing and monitoring various diseases. A comprehensive urine proteome database, generated from a variety of urine samples with different disease conditions, can serve as a reference resource for facilitating discovery of potential urine protein biomarkers. Herein, we present a urine proteome database generated from multiple datasets using 2D LC-MS/MS proteome profiling of urine samples from healthy individuals (HI), renal transplant patients ...[more]

PMID: 33928097

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