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Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria: proteomics

ABSTRACT: We analyzed changes in cellular components and processes during NiV infection through a time-course exposure using live virus and individual genes (or combinations) via transfection. Our multi-omics approach has displayed an enrichment in mitochondrial proteins. This enrichment phenotype was also observed when we combine viral glycoprotein genes in transfection experiments. These analyses provide an atlas of cellular changes during NiV infections, helpful in designing therapeutics against rapidly growing Henipavirus genes and related infections.

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Joshua N. Adkins Hector Aguilar-Carreno

PROVIDER: MSV000086754 | MassIVE | Sat Jan 23 01:31:00 GMT 2021

SECONDARY ACCESSION(S): PXD023764

REPOSITORIES: MassIVE

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