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Phosphoproteomics of ATR Signaling in Prophase I of Mouse Meiosis

ABSTRACT: Here we used phosphoproteomics to define meiosis-specific ATR signaling events during prophase I in mice following chemical and genetic ablation of ATR signaling. Quantitative analysis of phosphoproteomes obtained after tissue-specific genetic ablation of the ATR activating 9-1-1 complex or treatment with ATR inhibitor revealed over 49,800 phosphorylation sites from testes samples, of which 401 phosphorylation sites were found to be dependent on both the 9-1-1 complex and ATR kinase.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Marcus Smolka

PROVIDER: MSV000086764 | MassIVE | Mon Jan 25 17:13:00 GMT 2021

SECONDARY ACCESSION(S): PXD023803

REPOSITORIES: MassIVE

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