Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Sp. (ncbitaxon:10095)
SUBMITTER: Frank Schroeder
PROVIDER: MSV000086890 | MassIVE | Tue Feb 16 14:24:00 GMT 2021
REPOSITORIES: MassIVE
Arifuzzaman Mohammad M Won Tae Hyung TH Li Ting-Ting TT Yano Hiroshi H Digumarthi Sreehaas S Heras Andrea F AF Zhang Wen W Parkhurst Christopher N CN Kashyap Sanchita S Jin Wen-Bing WB Putzel Gregory Garbès GG Tsou Amy M AM Chu Coco C Wei Qianru Q Grier Alex A Worgall Stefan S Guo Chun-Jun CJ Schroeder Frank C FC Artis David D
Nature 20221102 7936
Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented short-chain fatty acid metabolites<sup>1,2</sup>, although the immunoregulatory roles of most fibre diets and their microbiota-derived metabolites remain poorly defined. Here, using microbial sequencing and untargeted metabolomics, we show that a diet of inulin fibre alters the composition of the mouse microbiota and the levels of microbiota-derived metabolites, notably bile acids. This metabo ...[more]