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Global profiling of human cyotrophoblast differentiation/invasion

ABSTRACT: We profiled purified human cytotrophoblasts derived from second trimester placenta across four culture time points (0-39 h).

INSTRUMENT(S): TripleTOF 5600+

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Susan Fisher

PROVIDER: MSV000086970 | MassIVE | Tue Mar 02 10:25:00 GMT 2021

REPOSITORIES: MassIVE

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Global proteomic analyses of human cytotrophoblast differentiation/invasion.

Chen Hao H Williams Katherine E KE Kwan Elaine Y EY Kapidzic Mirhan M Puckett Kenisha A KA Aburajab Rayyan K RK Robinson Joshua F JF Fisher Susan J SJ

Development (Cambridge, England) 20210701 13

During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper fetal growth and development. A subset of these CTBs differentiate along an invasive pathway, penetrating the decidua and anchoring the placenta to the uterus. A crucial hurdle in pregnancy is the ability of these cells to migrate, invade and remodel spiral arteries, ensuring adequate blood flow to nourish the developing fetus. Although advances contin ...[more]

PMID: 34121116

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