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Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.) mediated neuroprotection in a rotenone-induced cellular model of Parkinsons disease

ABSTRACT: In the present study we carried out global and targeted metabolomics of differentiated IMR32 cells to study the neuroprotective mechanism of Yashtimadhu (Glycyrrhiza glabra L.) in rotenone induced cellular model of parkinsons disease. Our mass spectrometry data highlighted 2403 and 2934 aligned metabolites from the positive and negative modes respectively. Among the aligned metabolites, 756 metabolites from positive and 731 metabolites from negative polarity, were mapped to a known metabolite, and the others remained unassigned. A total of 1,102 non-redundant metabolites from the positive and negative modes were assigned.

INSTRUMENT(S): QTRAP 6500

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: T. S. Keshava Prasad  

PROVIDER: MSV000088036 | MassIVE | Tue Aug 31 05:24:00 BST 2021

REPOSITORIES: MassIVE

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Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation.

Karthikkeyan Gayathree G   Behera Santosh Kumar SK   Upadhyay Shubham Sukerndeo SS   Pervaje Ravishankar R   Prasad Thottethodi Subrahmanya Keshava TSK   Modi Prashant Kumar PK  

Phytotherapy research : PTR 20220320 5

Parkinson's disease (PD) is an age-associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu, prepared from the dried roots of Glycyrrhiza glabra L. (licorice) in the rotenone-induced cellular model of PD. Retinoic acid-differentiated IMR-32 cells were treated with rotenone (PD model) and Yashtimadhu extract. Mass  ...[more]

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