A Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenograft Models of Triple Negative Breast Cancer
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ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Michael T. Lewis
PROVIDER: MSV000088233 | MassIVE | Fri Oct 15 12:04:00 BST 2021
REPOSITORIES: MassIVE
Publications
Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts.
Petrosyan Varduhi V Dobrolecki Lacey E LE LaPlante Emily L EL Srinivasan Ramakrishnan Rajaram RR Bailey Matthew H MH Welm Alana L AL Welm Bryan E BE Lewis Michael T MT Milosavljevic Aleksandar A
NPJ breast cancer 20220910 1
TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment. ...[more]
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