Dataset Information
The Mycobacterium tuberculosis O-phosphorylation landscape
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF-X, Q Exactive Plus
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773)
SUBMITTER: 
Christoph Grundner
PROVIDER: MSV000088254 | MassIVE | Thu Oct 21 23:56:00 BST 2021
SECONDARY ACCESSION(S): PXD029278
REPOSITORIES: MassIVE
Publications
The Mycobacterium tuberculosis protein O-phosphorylation landscape.
Nature microbiology 20230123 3
Bacterial phosphosignalling has been synonymous with two-component systems and their histidine kinases, but many bacteria, including Mycobacterium tuberculosis (Mtb), also code for Ser/Thr protein kinases (STPKs). STPKs are the main phosphosignalling enzymes in eukaryotes but the full extent of phosphorylation on protein Ser/Thr and Tyr (O-phosphorylation) in bacteria is untested. Here we explored the global signalling capacity of the STPKs in Mtb using a panel of STPK loss-of-function and overe ...[more]
