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Dysferlin deficient mice proteomics

ABSTRACT: Investigation of age-dependent changes in the proteomic profile of Dysferlin-deficient mouse skeletal muscle relative to healthy muscle.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Stephanie Cologna

PROVIDER: MSV000088639 | MassIVE | Tue Jan 04 15:30:00 GMT 2022

REPOSITORIES: MassIVE

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Relative quantification of progressive changes in healthy and dysferlin-deficient mouse skeletal muscle proteomes.

Golding Adriana E AE Li Wenping W Blank Paul S PS Cologna Stephanie M SM Zimmerberg Joshua J

Muscle & nerve 20230914 5

<h4>Introduction/aims</h4>Individuals with dysferlinopathies, a group of genetic muscle diseases, experience delay in the onset of muscle weakness. The cause of this delay and subsequent muscle wasting are unknown, and there are currently no clinical interventions to limit or prevent muscle weakness. To better understand molecular drivers of dysferlinopathies, age-dependent changes in the proteomic profile of skeletal muscle (SM) in wild-type (WT) and dysferlin-deficient mice were identified.<h4 ...[more]

PMID: 37706611

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