Proteomics

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Label-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.


ABSTRACT: Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei guo   David W. Speicher  

PROVIDER: MSV000088846 | MassIVE | Wed Feb 16 06:31:00 GMT 2022

SECONDARY ACCESSION(S): PXD031715

REPOSITORIES: MassIVE

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Publications


The lack of tumor infiltration by CD8<sup>+</sup> T cells is associated with poor patient response to anti-PD-1 therapy. Understanding how tumor infiltration is regulated is key to improving treatment efficacy. Here, we report that phosphorylation of HRS, a pivotal component of the ESCRT complex involved in exosome biogenesis, restricts tumor infiltration of cytolytic CD8<sup>+</sup> T cells. Following ERK-mediated phosphorylation, HRS interacts with and mediates the selective loading of PD-L1 t  ...[more]

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