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Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia

ABSTRACT: A deep-scale proteome and phosphoproteome database from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls including 3 lineage-depleted and 3 CD34+ selected bone marrows.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Timothy J. Ley

PROVIDER: MSV000089012 | MassIVE | Mon Mar 07 08:06:00 GMT 2022

SECONDARY ACCESSION(S): PXD032110

REPOSITORIES: MassIVE

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Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.

Kramer Michael H MH Zhang Qiang Q Sprung Robert R Day Ryan B RB Erdmann-Gilmore Petra P Li Yang Y Xu Ziheng Z Helton Nichole M NM George Daniel R DR Mi Yiling Y Westervelt Peter P Payton Jacqueline E JE Ramakrishnan Sai M SM Miller Christopher A CA Link Daniel C DC DiPersio John F JF Walter Matthew J MJ Townsend R Reid RR Ley Timothy J TJ

Blood 20220901 13

We have developed a deep-scale proteome and phosphoproteome database from 44 representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 healthy bone marrow-derived controls. After confirming data quality, we orthogonally validated several previously undescribed features of AML revealed by the proteomic data. We identified examples of posttranscriptionally regulated proteins both globally (ie, in all AML samples) and also in patients with recurrent AML driver mutations. ...[more]

PMID: 35895896

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