Loss of ADAM15 exacerbates transition to decompensated hypertrophy through activation of calcineurin pathway
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Olivier Julien
PROVIDER: MSV000089016 | MassIVE | Mon Mar 07 11:57:00 GMT 2022
REPOSITORIES: MassIVE
Publications
Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway.
Aujla Preetinder K PK Hu Mei M Hartley Bridgette B Kranrod Joshua W JW Viveiros Anissa A Kilic Tolga T Owen Caroline A CA Oudit Gavin Y GY Seubert John M JM Julien Olivier O Kassiri Zamaneh Z
Hypertension (Dallas, Tex. : 1979) 20221104 1
<h4>Background</h4>Myocardial hypertrophy and dilation are key features of cardiomyopathies and involve several cellular and molecular events. ADAMs (a disintegrin and metalloproteinases) are membrane-bound proteinases with diverse functions whose role in heart disease remains underexplored. ADAM15 is expressed in the heart and is downregulated in the failing human heart. We investigated the role ADAM15 in pressure overload cardiomyopathy.<h4>Methods</h4>We assessed ADAM15 levels in myocardial s ...[more]
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