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Leveraging the CSF proteome toward minimally-invasive diagnostics and biological characterization of brain malignancies

ABSTRACT: To identify diagnostic and prognostic cerebrospinal fluid (CSF) proteomic signatures in glioblastoma (GBM), brain metastases (BM), normal pressure hydrocephalus (NPH) and central nervous system lymphoma (CNSL), CSF samples were retrospectively retrieved from the Penn State Neuroscience Biorepository and profiled using shotgun proteomics. Proteomic signatures were identified using machine learning classifiers and survival analyses.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Thomas Kislinger

PROVIDER: MSV000089062 | MassIVE | Tue Mar 15 06:15:00 GMT 2022

REPOSITORIES: MassIVE

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