Dataset Information
Temporal Profiling of PyMT Tumour Matrisome during Progression
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Thomas R. Cox
PROVIDER: MSV000089167 | MassIVE | Wed Mar 30 21:21:00 BST 2022
SECONDARY ACCESSION(S): PXD032876
REPOSITORIES: MassIVE
Publications
Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.
Nature communications 20220806 1
The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours including breast cancer involve the significant accumulation of type I collagen. However, recently it has become clear that the precise distribution and organisation of matrix molecules such as collagen I is equally as important in the tumour as their abundance. Cancer-associated fibroblasts (CAFs) coexist wit ...[more]
