Dataset Information

Label-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice

ABSTRACT: Label-free semi-quantitative proteome profiling of retinas at P5 of Wild type and Cfap418-/- mice

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jun Yang

PROVIDER: MSV000089334 | MassIVE | Fri Apr 29 07:02:00 BST 2022

SECONDARY ACCESSION(S): PXD033564

REPOSITORIES: MassIVE

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Publications

Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations.

Clark Anna M AM Yu Dongmei D Neiswanger Grace G Zhu Daniel D Zou Junhuang J Maschek J Alan JA Burgoyne Thomas T Yang Jun J

JCI insight 20240109 1

Syndromic ciliopathies and retinal degenerations are large heterogeneous groups of genetic diseases. Pathogenic variants in the CFAP418 gene may cause both disorders, and its protein sequence is evolutionarily conserved. However, the disease mechanism underlying CFAP418 mutations has not been explored. Here, we apply quantitative lipidomic, proteomic, and phosphoproteomic profiling and affinity purification coupled with mass spectrometry to address the molecular function of CFAP418 in the retina ...[more]

PMID: 37971880

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